Michael T. Osterholm and Mark Olshaker
Less than five years after the outbreak of COVID-19, the world remains vulnerable to another pandemic. Over the past five months, a mutated strain of the H5N1 influenza virus detected in dairy cattle poses a potential risk for a pandemic-causing virus. Yet governments and international organizations have done far too little to prepare for such a scenario, despite the lessons they should have learned from the global battle with COVID-19.
After the COVID-19 crisis revealed the shortcomings of the global public health response system, many assumed that governments and international organizations would strive to fix the most obvious problems. Given the catastrophic human and economic costs of the pandemic, countries had a strong incentive to start spending heavily on developing new generations of more protective influenza and coronavirus vaccines, as well as to greatly expand global manufacturing and distribution networks. But this has not happened. At current funding levels, it will likely take a decade or longer to develop more effective and longer-lasting vaccines. Although there are groups at work on new treatments and other antiviral initiatives, on the whole, global society does not appear to be much more prepared for a future coronavirus or influenza pandemic than it was five years ago.
The resurgence of H5N1 influenza in humans and animals has highlighted these failures. Although the virus was identified in the 1990s, over the last 20 years it has continued to mutate, reinventing itself over and over again. Today, it is infecting millions of birds, but it has also become more capable of spilling over into at least 40 species of mammals. It still cannot easily transmit between humans, but infections in dairy cattle, which have influenza receptors for both avian and human influenza viruses in their udders, demonstrate the risk for a new pandemic.
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